(Μ,Łambda)-CCMA-ES for Constrained Optimization with an Application in Pharmacodynamics

Citation:

G. Arampatzis, D. Wälchli, P. Weber, H. Rästas, and P. Koumoutsakos, “(Μ,Łambda)-CCMA-ES for Constrained Optimization with an Application in Pharmacodynamics,” in PASC '19: Proceedings of the Platform for Advanced Scientific Computing Conference, PASC '19, 2019, pp. 1-9.

Abstract:

We present the algorithm CCMA-ES, an extension to CMA-ES, an evolution strategy that has shown to perform well in a broad range of black-box optimization problems. The (µ, λ)-CMA-ES effectively handles nonlinear nonconvex functions but faces difficulties in constrained optimization problems. We introduce viability boundaries to improve the search for an initial point in the valid domain and adapt the covariance matrix using normal approximations to maintain the inequality constraints. Using benchmark problems from 2006 CEC we compare the performance of CCMA-ES with a state of the art optimization algorithm (mViE) showing favorable results. Finally, CCMA-ES is applied to a pharmacodynamics problem describing tumor growth, and we demonstrate that CCMA-ES outperforms mViE in terms of the objective function value and total function evaluations.

Publisher's Version

Last updated on 09/17/2021