The genetic program that directs the growth and precise shape of an organ is not known. Developmental genetics has provided us with the toolkit (morphogens, transcription factors etc.) that is used to make an organ but we do not know how this toolkit is used to make a Drosophila wing of reproducible size and form. The answer to this question requires the quantitative description of wing development at a systems level and the ability to simulate the process at the molecular, cellular, and tissue level.
Multiscale and multiphysics particle simulations of wing development
In this project (started 10/2008) we collaborate with biologists using the Drosophila wing as a model uniquely suited for a systems biology approach. The development of the Drososphila wing is regulated at various levels of complexity ranging from gene regulation and molecular signaling, to cell architecture and biomechanical properties of tissues.
We develop a framework within which computational models of development are integrated with data in order to analyze phenomena on multiple spatial and temporal scales. The uniqueness of our approach is characterized by the advanced computational techniques that have been developed in our labs and the embedding of the modeling effort in an experimental environment in order to introduce a systematic development of biologically informed computational methods for data analysis and predictive modeling. The project is conducted as part of the SystemsX initiative, (under the title WingX), in collaboration with University of Zurich, University of Basel, EPF Lausanne and University of Lausanne.
Drosophila wing as a model organ
The fruit fly – Drosophila melanogaster – has been a crucial model organism for the discovery of basic principles in development. Decades of developmental, cell biological, and above all genetic research have provided a detailed understanding of the genetic networks that govern growth and patterning of this organism and specifically of its wing and thus provide a solid foundation for a systems approach.
People: Gerardo Tauriello, Michael Bergdorf, Basil Bayati
People: Ernst Hafen (ETH Zurich, IMSB), Tinri Aegerter (University of Zurich, IMB), Dario Floreano (EPFL, LIS)
Funding: SystemsX
2011
- G. Schwank, G. Tauriello, R. Yagi, E. Kranz, P. Koumoutsakos, and K. Basler, “Antagonistic growth regulation by dpp and fat drives uniform cell proliferation,” Dev. Cell, vol. 20, iss. 1, p. 123–130, 2011.